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Novel plasma and imaging biomarkers in heart failure with preserved ejection fraction

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journal contribution
posted on 12.12.2016, 19:12 by Prathap Kanagala, Iain B. Squire, Leong L. Ng, Gerry P. McCann
Existing diagnostic guidelines for heart failure with preserved ejection fraction (. HFPEF) primarily comprise natriuretic peptides and echocardiographic assessment, highlighting the role of diastolic dysfunction. However, recent discoveries of novel plasma markers implicated in pathophysiology of heart failure and technological advances in imaging provide additional biomarkers which are potentially applicable to HFPEF. The evidence base for plasma extra-cellular matrix (ECM) peptides, galectin-3, ST2, GDF-15 and pentraxin-3 is reviewed. Furthermore, the capabilities of novel imaging techniques to assess existing parameters (e.g. left ventricular ejection fraction, systolic & diastolic function, chamber size) and additional derangements of the ECM, myocardial mechanics and ischaemia evaluation are addressed.

Funding

This work has been supported by funding from the National Institute for Health Research (NIHR) Cardiovascular Biomedical Research Unit and Department of Cardiovascular Sciences, University Hospitals of Leicester.

History

Citation

International Journal of Cardiology: Heart and Vasculature , 2015, 9, pp. 55-62

Author affiliation

/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicine/Department of Cardiovascular Sciences

Version

VoR (Version of Record)

Published in

International Journal of Cardiology: Heart and Vasculature

Publisher

Elsevier

issn

2352-9067

Acceptance date

25/07/2015

Copyright date

2015

Available date

12/12/2016

Publisher version

http://www.sciencedirect.com/science/article/pii/S2352906715300166

Notes

Supplementary data to this article can be found online at http://dx.doi.org/10.1016/j.ijcha.2015.07.004.

Language

en

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