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Nucleotide sequence of conjugative prophage Φ1207.3 (formerly Tn1207.3) carrying the mef(A)/msr(D) genes for efflux resistance to macrolides in Streptococcus pyogenes

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posted on 24.02.2016, 11:10 by F. Iannelli, M. Santagati, F. Santoro, Marco Rinaldo Oggioni, S. Stefani, G. Pozzi
Genetic element Φ1207.3 (formerly Tn1207.3) is a prophage of Streptococcus pyogenes which carries the macrolide efflux resistance genes mef(A)/msr(D) and is capable of conjugal transfer among streptococci. Complete nucleotide sequence showed that Φ1207.3 is 52,491 bp in length and contained 58 open reading frames (ORFs). A manual homology-based annotation with functional prediction of the hypothetical gene product was possible only for 34 out of 58 ORFs. Φ1207.3 codes for two different C-methylation systems, several phage structural genes, a lysis cassette (composed by a holin and a peptidoglycan hydrolase), and three site-specific resolvases of the serine recombinase family.

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Citation

Frontiers in Microbiology, 2014, 5 : 687

Author affiliation

/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/MBSP Non-Medical Departments/Department of Genetics

Version

VoR (Version of Record)

Published in

Frontiers in Microbiology

Publisher

Frontiers Research Foundation

eissn

1664-302X

Acceptance date

21/11/2014

Copyright date

2014

Available date

24/02/2016

Publisher version

http://journal.frontiersin.org/article/10.3389/fmicb.2014.00687/abstract

Language

en

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