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Prediction error and trace dominance determine the fate of fear memories after post-training manipulations.

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journal contribution
posted on 10.01.2018, 12:31 by Joaquín M. Alfei, Roque I. Ferrer Monti, Victor A. Molina, Adrián M. Bueno, Gonzalo P. Urcelay
Different mnemonic outcomes have been observed when associative memories are reactivated by CS exposure and followed by amnestics. These outcomes include mere retrieval, destabilization-reconsolidation, a transitional period (which is insensitive to amnestics), and extinction learning. However, little is known about the interaction between initial learning conditions and these outcomes during a reinforced or nonreinforced reactivation. Here we systematically combined temporally specific memories with different reactivation parameters to observe whether these four outcomes are determined by the conditions established during training. First, we validated two training regimens with different temporal expectations about US arrival. Then, using Midazolam (MDZ) as an amnestic agent, fear memories in both learning conditions were submitted to retraining either under identical or different parameters to the original training. Destabilization (i.e., susceptibly to MDZ) occurred when reactivation was reinforced, provided the occurrence of a temporal prediction error about US arrival. In subsequent experiments, both treatments were systematically reactivated by nonreinforced context exposure of different lengths, which allowed to explore the interaction between training and reactivation lengths. These results suggest that temporal prediction error and trace dominance determine the extent to which reactivation produces the different outcomes.

Funding

This work was supported by a grant from Secretaría de Ciencia y Técnica (SeCyT) from the Universidad Nacional de Córdoba, Argentina, to A.M.B. J.M.A was supported by a pregraduate SeCyT studentship. R.I.F.M. was supported by a doctoral SeCyT studentship.

History

Citation

Learning and Memory, 2015, 22 (8), pp. 385-400

Author affiliation

/Organisation/COLLEGE OF LIFE SCIENCES/Biological Sciences/Neuroscience, Psychology and Behaviour

Version

VoR (Version of Record)

Published in

Learning and Memory

Publisher

Cold Spring Harbor Laboratory Press

issn

1072-0502

eissn

1549-5485

Acceptance date

05/06/2015

Copyright date

2015

Available date

10/01/2018

Publisher version

http://learnmem.cshlp.org/content/22/8/385

Language

en