Proenkephalin in Heart Failure.pdf (393.6 kB)
Download file

Proenkephalin in Heart Failure

Download (393.6 kB)
journal contribution
posted on 21.11.2017, 15:26 by Daniel Chu Siong Chan, Thong Huy Cao, Leong Loke Ng
The opioid system is activated in heart failure, which may be cardioprotective but may also be counter-regulatory. Recently, systemic proenkephalin activation has been investigated in various conditions predicting mortality and kidney injury. In acute heart failure, proenkephalin independently predicts mortality and heart failure rehospitalization in addition to traditional risk markers. It also predicts worsening renal function, increasingly recognized as an important risk predictor for poor outcome in heart failure. This article explores the role of enkephalins and delta-opioid receptors in the heart, then reviews studies measuring proenkephalin levels in the circulation and their associations with prognosis.

Funding

T.H. Cao is funded by the John and Lucille van Geest Foundation. D.C.S. Chan is funded by the British Heart Foundation on grant FS/15/10/31223.

History

Citation

Heart Failure Clinics, 2018, 14(1), pp. 1-11

Author affiliation

/Organisation/COLLEGE OF LIFE SCIENCES/School of Medicine/Department of Cardiovascular Sciences

Version

AM (Accepted Manuscript)

Published in

Heart Failure Clinics

Publisher

Elsevier

issn

1551-7136

Copyright date

2017

Available date

28/09/2018

Publisher version

http://www.sciencedirect.com/science/article/pii/S1551713617300831?via=ihub

Notes

The file associated with this record is under embargo until 12 months after publication, in accordance with the publisher's self-archiving policy. The full text may be available through the publisher links provided above.

Language

en