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Prognostic molecular markers in cholangiocarcinoma: A systematic review.

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journal contribution
posted on 21.01.2009, 12:46 by Christopher D. Briggs, Christopher P. Neal, Christopher D. Mann, William P. Steward, Margaret M. Manson, David P. Berry
The worldwide incidence of cholangiocarcinoma (CC) is steadily rising, the United Kingdom incidence now exceeding 1000 cases per year. It is an aggresive malignancy typified by unresponsiveness to existing chemotherapy and radiotherapy regimes in the vast majority of cases. Surgery offers the only hope of a cure, though postoperative disease recurrence is common, with 5-year survival rates following resection of less then 25%. Developments in molecular techniques and improved understanding of the basis of carcinogenesis in CC has led to examination of the role of biomarkers in predicting poor outcome. This systematic review examines published evidence relating to the prognostic significance of these molecular markers in CC. Of the molecular markers which have been investigated to date p53 mutation, cyclins, proliferation indices, mucins, CA19-9, CRP, and aneuploidy appear to hold significant potential as predictors of outcome in CC. These and other biomarkers may themselves represent novel therapeutic targets for CC.

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Citation

European Journal of Cancer, 2009, 45 (1), pp. 33-47.

Published in

European Journal of Cancer

Publisher

Elsevier.

issn

0959-8049

Available date

21/01/2009

Publisher version

http://www.sciencedirect.com/science/article/pii/S0959804908006825

Language

en

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