bio-2016-0029.pdf (1.02 MB)
Download file

Quantitative analysis of methyl and propyl parabens in neonatal DBS using LC-MS/MS.

Download (1.02 MB)
journal contribution
posted on 15.11.2016, 09:54 by S. Yakkundi, Hussain Mulla, Hitesh Pandya, M. A. Turner, J. McElnay
AIM: Excipients are used to overcome the chemical, physical and microbiological challenges posed by developing formulated medicines. Both methyl and propyl paraben are commonly used in pediatric liquid formulations. There is no data on systemic exposure to parabens in neonates. The European Study of Neonatal Exposure to Excipients project has investigated this. Results & methodology: DBS sampling was used to collect opportunistic blood samples. Parabens were extracted from the DBS and analyzed using a validated LC-MS/MS assay. DISCUSSION & CONCLUSION: The above assay was applied to analyze neonatal DBS samples. The blood concentrations of parabens in neonates confirm systemic exposure to parabens following administration of routine medicines.

Funding

The work described here was funded under ERA-NET PRIOMEDCHILD programme. In the UK, this was funded by MRC Grant G1100158 to the Principal Investigator (MA Turner).

History

Citation

Bioanalysis, 2016, 8 (11), pp. 1173-1182

Author affiliation

/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicine/Department of Infection, Immunity and Inflammation

Version

VoR (Version of Record)

Published in

Bioanalysis

Publisher

Future Science

issn

1757-6180

eissn

1757-6199

Acceptance date

13/04/2016

Available date

15/11/2016

Publisher version

http://www.future-science.com/doi/10.4155/bio-2016-0029

Language

en