Full+manuscript_CLEAN.pdf (431.7 kB)
Download file

Reallocating sitting time to standing or stepping through isotemporal analysis: associations with markers of chronic low-grade inflammation.

Download (431.7 kB)
journal contribution
posted on 26.01.2018, 17:41 by Joseph Henson, Charlotte L. Edwardson, Danielle H. Bodicoat, Kishan Bakrania, Melanie J. Davies, Kamlesh Khunti, Duncan C. S. Talbot, Thomas Yates
Although high levels of sitting time are adversely related to health, it is unclear whether moving from sitting to standing provides a sufficient stimulus to elicit benefits upon markers of chronic low-grade inflammation in a population at high risk of type 2 diabetes (T2DM). Three hundred and seventy two participants (age = 66.8 ± 7.5years; body mass index (BMI) = 31.7 ± 5.5kg/m2; Male = 61%) were included. Sitting, standing and stepping was determined using the activPAL3TM device. Linear regression modelling employing an isotemporal substitution approach was used to quantify the association of theoretically substituting 60 minutes of sitting per day for standing or stepping on interleukin-6 (IL-6), C-reactive protein (CRP) and leptin. Reallocating 60 minutes of sitting time per day for standing was associated with a -4% (95% CI -7%, -1%) reduction in IL-6 (p = 0.048). Reallocating 60 minutes of sitting time for light stepping was also associated with lower IL-6 levels (-28% (-46%, -4%; p = 0.025)). Substituting sitting for moderate-to-vigorous (MVPA) stepping was associated with lower CRP (-41% (-75%, -8%; p = 0.032)), leptin (-24% (-34%, -12%; p ≤ 0.001)) and IL-6 (-16% (-28%, 10%; p = 0.036). Theoretically replacing 60 minutes of sitting per day with an equal amount of either standing or stepping yields beneficial associations upon markers of chronic-low grade inflammation.

Funding

This work was supported by The National Institute for Health Research Collaboration for Leadership in Applied Health Research and Care - Leicestershire, Northamptonshire and Rutland (NIHR CLAHRC – LNR) and East Midlands (NIHR CLAHRC EM). The research was supported by the NIHR Leicester Biomedical Research Centre which is a partnership between University Hospitals of Leicester NHS Trust, Loughborough University and the University of Leicester and the University of Leicester Clinical Trials Unit.

History

Citation

Journal of Sports Sciences, 2017, pp. 1-8

Author affiliation

/Organisation/COLLEGE OF LIFE SCIENCES/School of Medicine/Diabetes Research Centre

Version

AM (Accepted Manuscript)

Published in

Journal of Sports Sciences

Publisher

Taylor & Francis for British Association of Sport and Exercise Sciences

issn

0264-0414

eissn

1466-447X

Acceptance date

22/11/2017

Copyright date

2017

Available date

21/05/2019

Publisher version

http://www.tandfonline.com/doi/full/10.1080/02640414.2017.1405709

Notes

The file associated with this record is under embargo until 18 months after publication, in accordance with the publisher's self-archiving policy. The full text may be available through the publisher links provided above.

Language

en

Usage metrics

Categories

Exports