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Relationship between blood and bronchial submucosal eosinophilia and reticular basement membrane thickening in chronic obstructive pulmonary disease

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journal contribution
posted on 17.02.2016, 09:51 by Osama Eltboli, Vijay Mistry, Bethan Barker, Christopher Edward Brightling
A sputum eosinophilia is observed in 10-40% of COPD subjects. The blood eosinophil count is a biomarker of sputum eosinophilia, but whether it is associated with bronchial submucosal eosinophils is unclear. In 20 COPD subjects and 21 controls we assessed the number of bronchial submucosal eosinophils and reticular basement membrane thickening and found these were positively correlated with the blood eosinophil percentage. In COPD, blood eosinophils are a good biomarker of bronchial eosinophilia and remodelling.

History

Citation

Respirology, 2015, 20 (4), pp. 667-670

Author affiliation

/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicine/Department of Infection, Immunity and Inflammation

Version

VoR (Version of Record)

Published in

Respirology

Publisher

Wiley for Asian Pacific Society of Respirology

issn

1323-7799

eissn

1440-1843

Acceptance date

29/11/2014

Copyright date

2015

Available date

17/02/2016

Publisher version

http://onlinelibrary.wiley.com/doi/10.1111/resp.12475/abstract

Language

en