Repression of telomere-associated genes by microglia activation in neuropsychiatric disease.
journal contributionposted on 17.06.2019, 10:57 by G Kronenberg, R Uhlemann, J Schöner, S Wegner, V Boujon, N Deigendesch, M Endres, K Gertz
Microglia senescence may promote neuropsychiatric disease. This prompted us to examine the relationship between microglia activation states and telomere biology. A panel of candidate genes associated with telomere maintenance, mitochondrial biogenesis, and cell-cycle regulation were investigated in M1- and M2-polarized microglia in vitro as well as in MACS-purified CD11b+ microglia/brain macrophages from models of stroke, Alzheimer's disease, and chronic stress. M1 polarization, ischemia, and Alzheimer pathology elicited a strikingly similar transcriptomic profile with, in particular, reduced expression of murine Tert. Our results link classical microglia activation with repression of telomere-associated genes, suggesting a new mechanism underlying microglia dysfunction.
This work was supported by the Deutsche Forschungsgemeinschaft (GE2576/3-1 to K.G; DFG KR2956/5-1 to G.K; Exc257 to M.E.), the Bundesministerium für Bildung und Forschung (Center for Stroke Research Berlin to G.K., K.G. and M.E.), the European Union’s Seventh Framework Programme (FP7/HEALTH.2013.2.4.2-1) under grant agreement n° 602354 (Counterstroke consortium to K.G. and M.E.), the German Center for Neurodegenerative Disease (DZNE to M.E.), the German Center for Cardiovascular Research (DZHK to M.E.), and the Corona Foundation (to M.E.).
CitationEuropean Archives of Psychiatry and Clinical Neuroscience, 2017, 267 (5), pp. 473-477
Author affiliation/Organisation/COLLEGE OF LIFE SCIENCES/School of Medicine/Department of Cardiovascular Sciences
VersionVoR (Version of Record)
Published inEuropean Archives of Psychiatry and Clinical Neuroscience
PublisherSpringer (part of Springer Nature)
Alzheimer’s diseaseMicrogliaMitochondrial biogenesisNeurodegenerative diseaseTelomeraseAnimalsCD11b AntigenCell PolarityCells, CulturedCyclin-Dependent Kinase Inhibitor p21CytokinesDisease Models, AnimalGene Expression RegulationInfarction, Middle Cerebral ArteryLipopolysaccharidesMaleMiceMice, Inbred C57BLMice, TransgenicMutationNF-E2-Related Factor 2Presenilin-1RNA, Messenger