Research in progress: Medical Research Council United Kingdom Refractory Asthma Stratification Programme (RASP-UK)..pdf (440.35 kB)
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Research in progress: Medical Research Council United Kingdom Refractory Asthma Stratification Programme (RASP-UK)

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journal contribution
posted on 08.06.2016, 10:35 by L. G. Heaney, R. Djukanovic, A. Woodcock, S. Walker, J. G. Matthews, I. D. Pavord, Peter Bradding, R. Niven, Christopher E. Brightling, R. Chaudhuri, J. R. Arron, D. F. Choy, D. Cowan, A. Mansur, A. Menzies-Gow, I. Adcock, K. F. Chung, C. Corrigan, P. Coyle, T. Harrison, S. Johnston, P. Howarth, J. Lordan, I. Sabroe, J. Bigler, D. Smith, M. Catley, R. May, L. Pierre, C. Stevenson, G. Crater, F. Keane, R. W. Costello, V. Hudson, D. Supple, T. Hardman
The UK Refractory Asthma Stratification Programme (RASP-UK) will explore novel biomarker stratification strategies in severe asthma to improve clinical management and accelerate development of new therapies. Prior asthma mechanistic studies have not stratified on inflammatory phenotype and the understanding of pathophysiological mechanisms in asthma without Type 2 cytokine inflammation is limited. RASP-UK will objectively assess adherence to corticosteroids (CS) and examine a novel composite biomarker strategy to optimise CS dose; this will also address what proportion of patients with severe asthma have persistent symptoms without eosinophilic airways inflammation after progressive CS withdrawal. There will be interactive partnership with the pharmaceutical industry to facilitate access to stratified populations for novel therapeutic studies.

History

Citation

Thorax, 2016, 71 (2), pp. 187-189

Author affiliation

/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicine/Department of Infection, Immunity and Inflammation

Version

VoR (Version of Record)

Published in

Thorax

Publisher

BMJ Publishing Group with British Thoracic Society (BTS)

eissn

1468-3296

Acceptance date

22/06/2015

Copyright date

2016

Available date

08/06/2016

Publisher version

http://thorax.bmj.com/content/71/2/187

Language

en

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