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Risk of cancer incidence and mortality associated with diabetes: A systematic review with trend analysis of 203 cohorts

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journal contribution
posted on 16.10.2020, 15:21 by Suping Ling, Karen Brown, Joanne K Miksza, Lynne M Howells, Amy Morrison, Eyad Issa, Thomas Yates, Kamlesh Khunti, Melanie J Davies, Francesco Zaccardi
Introduction
Whether the relative risk of cancer incidence and mortality associated with diabetes has changed over time is unknown.

Methods
On August 12th, 2020, we electronically searched for observational studies reporting on the association between diabetes and cancer. We estimated temporal trends in the relative risk of cancer incidence or mortality associated with diabetes and calculated the ratio of relative risk (RRR) comparing different periods.

Results
193 eligible articles, reporting data on 203 cohorts (56,852,381 participants; 3,735,564 incident cancer cases; 185,404 cancer deaths) and covering the period 1951-2013, were included. The relative risk of all–site cancer incidence increased between 1980 and 2000 [RRR 1990 vs.1980: (1.24; 95% CI: 1.16, 1.34); 2000 vs.1990: (1.23; 1.15, 1.31)] and stabilised thereafter at a relative risk of 1.2; the relative risk of all–site cancer mortality was constant at about 1.2 from 1980 to 2010. Both magnitudes and trends in relative risk varied across cancer sites: the relative risk of colorectal, female breast, and endometrial cancer incidence and pancreatic cancer mortality was constant during the observed years; it increased for bladder, stomach, kidney, and pancreatic cancer incidence until 2000; and decreased for liver while increased for prostate, colon and gallbladder cancer incidence after 2000.

Conclusions
Alongside the increasing prevalence of diabetes, the temporal patterns of the relative risk of cancer associated with diabetes may have contributed to the current burden of cancer in people with diabetes.

History

Citation

Nutrition, Metabolism and Cardiovascular Diseases, 2020, https://doi.org/10.1016/j.numecd.2020.09.023

Author affiliation

Diabetes Research Centre, College of Life Sciences

Version

AM (Accepted Manuscript)

Published in

Nutrition, Metabolism and Cardiovascular Diseases

Publisher

Elsevier BV

issn

0939-4753

Acceptance date

17/09/2020

Copyright date

2020

Available date

25/09/2021

Language

en