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SARS-CoV-2 vaccine uptake in a multi-ethnic UK healthcare workforce: A cross-sectional study

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posted on 18.11.2022, 15:54 authored by Christopher A Martin, Colette Marshall, Prashanth Patel, Charles Goss, David R Jenkins, Claire Ellwood, Linda Barton, Arthur Price, Nigel J Brunskill, Kamlesh Khunti, Manish Pareek

Background 

Healthcare workers (HCWs) and ethnic minority groups are at increased risk of COVID-19 infection and adverse outcomes. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination is now available for frontline UK HCWs; however, demographic/occupational associations with vaccine uptake in this cohort are unknown. We sought to establish these associations in a large UK hospital workforce. 


Methods and findings 

We conducted cross-sectional surveillance examining vaccine uptake amongst all staff at University Hospitals of Leicester NHS Trust. We examined proportions of vaccinated staff stratified by demographic factors, occupation, and previous COVID-19 test results (serology/PCR) and used logistic regression to identify predictors of vaccination status after adjustment for confounders. We included 19,044 HCWs; 12,278 (64.5%) had received SARS-CoV-2 vaccination. Compared to White HCWs (70.9% vaccinated), a significantly smaller proportion of ethnic minority HCWs were vaccinated (South Asian, 58.5%; Black, 36.8%; p < 0.001 for both). After adjustment for age, sex, ethnicity, deprivation, occupation, SARS-CoV-2 serology/PCR results, and COVID-19-related work absences, factors found to be negatively associated with vaccine uptake were younger age, female sex, increased deprivation, pregnancy, and belonging to any non-White ethnic group (Black: adjusted odds ratio [aOR] 0.30, 95% CI 0.26–0.34, p < 0.001; South Asian: aOR 0.67, 95% CI 0.62–0.72, p < 0.001). Those who had previously had confirmed COVID-19 (by PCR) were less likely to be vaccinated than those who had tested negative. Limitations include data being from a single centre, lack of data on staff vaccinated outside the hospital system, and that staff may have taken up vaccination following data extraction. 


Conclusions 

Ethnic minority HCWs and those from more deprived areas as well as younger staff and female staff are less likely to take up SARS-CoV-2 vaccination. These findings have major implications for the delivery of SARS-CoV-2 vaccination programmes, in HCWs and the wider population, and should inform the national vaccination programme to prevent the disparities of the pandemic from widening.

Funding

CAM is an NIHR academic clinical fellow (ACF-2018-11-004). KK is supported by NIHR Applied Research Collaboration East Midlands (ARC EM). KK and MP are supported by the NIHR Leicester Biomedical Research Centre (BRC). MP is supported by a NIHR Development and Skills Enhancement Award (NIHR301192) and funding from UKRI/MRC (MR/V027549/1).

History

Citation

Martin CA, Marshall C, Patel P, Goss C, Jenkins DR, Ellwood C, et al. (2021) SARS-CoV-2 vaccine uptake in a multi-ethnic UK healthcare workforce: A cross-sectional study. PLoS Med 18(11): e1003823. https://doi.org/10.1371/journal. pmed.1003823

Author affiliation

Department of Respiratory Sciences/NIHR Leicester Biomedical Research Centre

Version

VoR (Version of Record)

Published in

PLOS Medicine

Volume

18

Issue

11

Pagination

e1003823

Publisher

Public Library of Science (PLoS)

issn

1549-1277

eissn

1549-1676

Acceptance date

23/09/2021

Copyright date

2021

Available date

18/11/2022

Language

en

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