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Satellite Cell Function, Intramuscular Inflammation and Exercise in Chronic Kidney Disease

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journal contribution
posted on 22.05.2018, 09:15 by Tom F. O'Sullivan, Alice C. Smith, Emma L. Watson
Skeletal muscle wasting is a common feature of Chronic Kidney Disease (CKD) and is clinically relevant due to associations with quality of life, physical functioning, mortality and a number of co-morbidities. Satellite cells are a population of skeletal muscle progenitor cells responsible for accrual and maintenance of muscle mass by providing new nuclei to myofibres. Recent evidence from animal models and human studies indicates CKD may negatively affect satellite cell abundance and function in response to stimuli such as exercise and damage. The aim of this review is to collate recent literature on the effect of CKD on satellite cells, with a particular focus on the myogenic response to exercise in this population. Exercise is widely recognised as important for the maintenance of healthy skeletal muscle mass and is increasingly advocated in the care of a number of chronic conditions. Therefore, a greater understanding of the impact of uremia upon satellite cells and the possible altered myogenic response in CKD is required to inform strategies to prevent uremic cachexia.

Funding

This report is independent research supported by the National Institute for Health Research Leicester Biomedical Research Centre.

History

Citation

Clinical Kidney Journal, 2018, sfy052

Author affiliation

/Organisation/COLLEGE OF LIFE SCIENCES/School of Medicine/Department of Infection, Immunity and Inflammation

Version

VoR (Version of Record)

Published in

Clinical Kidney Journal

Publisher

Oxford University Press (OUP) for European Renal Association - European Dialysis and Transplant Association (ERA-EDTA)

issn

2048-8505

eissn

2048-8513

Acceptance date

18/05/2018

Copyright date

2018

Available date

05/09/2018

Publisher version

https://academic.oup.com/ckj/advance-article/doi/10.1093/ckj/sfy052/5061533

Language

en

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