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Selective and non-selective bottlenecks as drivers of the evolution of hypermutable bacterial loci

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journal contribution
posted on 19.05.2020, 13:24 by Megan De Ste Croix, Jonathan Holmes, Joseph J Wanford, E Richard Moxon, Marco R Oggioni, Christopher D Bayliss
Bottlenecks reduce the size of the gene pool within populations of all life forms with implications for their subsequent survival. Here, we examine the effects of bottlenecks on bacterial commensal-pathogens during transmission between, and dissemination within, hosts. By reducing genetic diversity, bottlenecks may alter individual or population-wide adaptive potential. A diverse range of hypermutable mechanisms have evolved in infectious agents that allow for rapid generation of genetic diversity in specific genomic loci as opposed to the variability arising from increased genome-wide mutation rates. These localised hypermutable mechanisms include multi-gene phase variation (PV) of outer membrane components, multi-allele PV of restriction systems and recombination-driven antigenic variation. We review selected experimental and theoretical (mathematical) models pertaining to the hypothesis that localised hypermutation (LH) compensates for fitness losses caused by bottlenecks and discuss whether bottlenecks have driven the evolution of hypermutable loci.

Funding

Biotechnology and Biological Sciences Research Council. Grant Number: MIDTP PhD studentship Medical Research Council. Grant Numbers: MR/S009264/1, MRC IMPACT PhD studentship

History

Citation

De Ste Croix, M, Holmes, J, Wanford, JJ, Moxon, ER, Oggioni, MR, Bayliss, CD. Selective and non‐selective bottlenecks as drivers of the evolution of hypermutable bacterial loci. Mol Microbiol. 2020; 113: 672– 681. https://doi.org/10.1111/mmi.14453

Published in

MOLECULAR MICROBIOLOGY

Volume

113

Issue

3

Pagination

672 - 681 (10)

Publisher

WILEY

issn

0950-382X

eissn

1365-2958

Acceptance date

09/01/2020

Copyright date

2020

Available date

17/03/2020

Publisher version

https://onlinelibrary.wiley.com/doi/full/10.1111/mmi.14453

Spatial coverage

England

Language

English