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Serine and glycine metabolism in cancer

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journal contribution
posted on 08.10.2015, 11:18 by Ivano Amelio, F. Cutruzzolá, Alexey Antonov, Massimiliano Agostini, Gerry Melino
Serine and glycine are biosynthetically linked, and together provide the essential precursors for the synthesis of proteins, nucleic acids, and lipids that are crucial to cancer cell growth. Moreover, serine/glycine biosynthesis also affects cellular antioxidative capacity, thus supporting tumour homeostasis. A crucial contribution of serine/glycine to cellular metabolism is through the glycine cleavage system, which refuels one-carbon metabolism; a complex cyclic metabolic network based on chemical reactions of folate compounds. The importance of serine/glycine metabolism is further highlighted by genetic and functional evidence indicating that hyperactivation of the serine/glycine biosynthetic pathway drives oncogenesis. Recent developments in our understanding of these pathways provide novel translational opportunities for drug development, dietary intervention, and biomarker identification of human cancers.

History

Citation

Trends in Biochemical Sciences, 2014, 39(4), 191–198

Version

VoR (Version of Record)

Published in

Trends in Biochemical Sciences

Publisher

Elsevier (Cell Press)

issn

0968-0004

eissn

0167-7640

Copyright date

2014

Available date

08/10/2015

Publisher version

http://www.sciencedirect.com/science/article/pii/S0968000414000280

Language

en

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