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Single-cell responses to face adaptation in the human medial temporal lobe.

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journal contribution
posted on 14.05.2015, 12:56 by Rodrigo Quian Quiroga, A. Kraskov, F. Mormann, I. Fried, C. Koch
We used a face adaptation paradigm to bias the perception of ambiguous images of faces and study how single neurons in the human medial temporal lobe (MTL) respond to the same images eliciting different percepts. The ambiguous images were morphs between the faces of two familiar individuals, chosen because at least one MTL neuron responded selectively to one but not to the other face. We found that the firing of MTL neurons closely followed the subjects' perceptual decisions--i.e., recognizing one person or the other. In most cases, the response to the ambiguous images was similar to the one obtained when showing the pictures without morphing. Altogether, these results show that many neurons in the medial temporal lobe signal the subjects' perceptual decisions rather than the visual features of the stimulus.

Funding

This work was supported by grants from NINDS, EPSRC, MRC, the NIMH, and the G. Harold & Leila Y. Mathers Charitable Foundation.

History

Citation

Neuron, 2014, 84 (2), pp. 363-369

Author affiliation

/Organisation/COLLEGE OF SCIENCE AND ENGINEERING/Department of Engineering

Version

VoR (Version of Record)

Published in

Neuron

Publisher

Elsevier (Cell Press)

issn

0896-6273

eissn

1097-4199

Available date

14/05/2015

Publisher version

http://www.sciencedirect.com/science/article/pii/S0896627314007946

Notes

PMCID: PMC4210637 Supplemental Information includes three figures and can be found with this article online at http://dx.doi.org/10.1016/j.neuron.2014.09.006.

Language

en