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Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation

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posted on 09.11.2015, 12:02 by María Soler Artigas, Louise V. Wain, Suzanne Miller, Abdul Kader Kheirallah, Jennifer E. Huffman, Ioanna Ntalla, Nick Shrine, Ma'en Obeidat, Holly Trochet, Wendy L. McArdle, Alexessander Couto Alves, Jennie Hui, Jing Hua Zhao, Peter K. Joshi, Alexander Teumer, Eva Albrecht, Medea Imboden, Rajesh Rawal, Lorna M. Lopez, Jonathan Marten, Stefan Enroth, Ida Surakka, Ozren Polasek, Leo-Pekka Lyytikäinen, Raquel Granell, Pirro G. Hysi, Claudia Flexeder, Anubha Mahajan, John Beilby, Yohan Bossé, Corry-Anke Brandsma, Harry Campbell, Christian Gieger, Sven Gläser, Juan R. González, Harald Grallert, Chris J. Hammond, Sarah E. Harris, Anna-Liisa Hartikainen, Caroline Hayward, Markku Heliövaara, John Henderson, Lynne Hocking, Momoko Horikoshi, Nina Hutri-Kähönen, Erik Ingelsson, Åsa Johansson, John P. Kemp, Ivana Kolcic, Ashish Kumar, Lars Lind, Erik Melén, Arthur W. Musk, Pau Navarro, David C. Nickle, Sandosh Padmanabhan, Olli T. Raitakari, Janina S. Ried, Samuli Ripatti, Holger Schulz, Robert A. Scott, Don D. Sin, John M. Starr, Ana Viñuela, Henry Völzke, Sarah H. Wild, Alan F. Wright, Tatijana Zemunik, Deborah L. Jarvis, Tim D. Spector, David M. Evans, Terho Lehtimäki, Veronique Vitart, Mika Kähönen, Ulf Gyllensten, Igor Rudan, Ian J. Deary, Stefan Karrasch, Nicole M. Probst-Hensch, Joachim Heinrich, Beate Koch, James F. Wilson, Nicholas J. Wareham, Alan L. James, Andrew P. Morris, Marjo-Riitta Jarvelin, Ian Sayers, David P. Strachan, Ian P. Hall, Martin D. Tobin, UK BiLEVE, Generation Scotland
Lung function measures are used in the diagnosis of chronic obstructive pulmonary disease. In 38,199 European ancestry individuals, we studied genome-wide association of forced expiratory volume in one second (FEV1), forced vital capacity (FVC) and FEV1/FVC with 1000 Genomes Project (Phase 1) imputed genotypes and followed up top associations in 54,550 Europeans. We identify 14 novel loci (P<5x10-8) in or near ENSA, RNU5F-1, KCNS3, AK097794, ASTN2, LHX3, CCDC91, TBX3, TRIP11, RIN3, TEKT5, LTBP4, MN1, AP1S2, and two novel signals at known loci NPNT and GPR126, providing a basis for new understanding of the genetic determinants of these traits and pulmonary diseases in which they are altered.

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Citation

Nature Communications, 2015, 6:8658

Author affiliation

/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicine/Department of Health Sciences

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VoR (Version of Record)

Published in

Nature Communications

Publisher

Nature Publishing Group

eissn

2041-1723

Acceptance date

27/08/2015

Copyright date

2015

Available date

26/01/2017

Publisher version

http://www.nature.com/articles/ncomms9658

Language

en

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