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Smell identification function in early-onset Alzheimer's disease and mild cognitive impairment

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journal contribution
posted on 01.02.2019, 13:37 by L Velayudhan, F Wilson-Morkeh, E Penney, AJM Jesu, S Baillon, T Brugha
Little is known about olfactory identification (OI) function in early-onset Alzheimer's disease (EOAD) and early-onset mild cognitive impairment (eoMCI) with age of onset <65 years. We aimed to study OI in EOAD compared with eoMCI and age-matched healthy controls (HC). Nineteen EOAD subjects with mild to moderate dementia, 17 with eoMCI, and 21 HC recruited as a convenience sample from memory services were assessed for cognition, behavioral symptoms, and activities for daily living. The OI was tested using the University of Pennsylvania smell identification test (UPSIT). EOAD participants performed worse compared with eoMCI and HC on cognitive tests and OI (p < 0.001). Although eoMCI had poorer cognitive scores compared to HC, they were similar in their OI function. OI correlated with attention (r = 0.494, p = 0.031), executive functions (r = 0.508, p = 0.026), and praxis (r = 0.455, p = 0.05) within the EOAD group. OI impairment was significantly associated with the diagnosis of EOAD versus eoMCI, but not with eoMCI when compared with HC. OI could potentially be useful in differentiating EOAD from eoMCI. Studies with late-life MCI patients showing OI impairment relative to HC may be attributed to a different disease process. Independent replication in a larger sample is needed to validate these findings.

Funding

This work was supported by Alzheimer’s Research UK (ARUK) East Midlands Network funding (RM62G0700 and RM62G0546)

History

Citation

Int Psychogeriatr, 2018, pp. 1-6

Author affiliation

/Organisation/COLLEGE OF LIFE SCIENCES/School of Medicine/Department of Health Sciences

Version

AM (Accepted Manuscript)

Published in

Int Psychogeriatr

Publisher

Cambridge University Press for International Psychogeriatric Association

eissn

1741-203X

Acceptance date

25/06/2018

Copyright date

2018

Available date

15/04/2019

Publisher version

https://www.cambridge.org/core/journals/international-psychogeriatrics/article/smell-identification-function-in-earlyonset-alzheimers-disease-and-mild-cognitive-impairment/B4BF97E7FE20F58EFBFEA7F749B512EE

Notes

The file associated with this record is under embargo until 6 months after publication, in accordance with the publisher's self-archiving policy. The full text may be available through the publisher links provided above.

Language

en