Strategies for Molecular Imprinting and the Evolution of MIP Nanoparticles as Plastic Antibodies - Synthesis and Applications
journal contributionposted on 07.05.2020, 10:59 by Doaa Refaat, Mohamed G Aggour, Ahmed A Farghali, Rashmi Mahajan, Jesper G Wiklander, Ian A Nicholls, Sergey A Piletsky
Materials that can mimic the molecular recognition-based functions found in biology are a significant goal for science and technology. Molecular imprinting is a technology that addresses this challenge by providing polymeric materials with antibody-like recognition characteristics. Recently, significant progress has been achieved in solving many of the practical problems traditionally associated with molecularly imprinted polymers (MIPs), such as difficulties with imprinting of proteins, poor compatibility with aqueous environments, template leakage, and the presence of heterogeneous populations of binding sites in the polymers that contribute to high levels of non-specific binding. This success is closely related to the technology-driven shift in MIP research from traditional bulk polymer formats into the nanomaterial domain. The aim of this article is to throw light on recent developments in this field and to present a critical discussion of the current state of molecular imprinting and its potential in real world applications.
CitationInternational Journal of Molecular Sciences, 2019, 20(24), 6304
Author affiliationDepartment of Chemistry
VersionVoR (Version of Record)
Published inInternational Journal of Molecular Sciences
Science & TechnologyLife Sciences & BiomedicinePhysical SciencesBiochemistry & Molecular BiologyChemistry, MultidisciplinaryChemistryassaymolecular imprintingnanoMIPprotein imprintingsensortherapeutic agentSOLID-PHASE SYNTHESISPOLYMER NANOPARTICLESDRUG-DELIVERYCROSS-LINKINGTETRACYCLINE ANTIBIOTICSSUBMICROMETER PARTICLESPROTEIN RECOGNITIONCONTROLLED-RELEASERIBONUCLEASE-AQUANTUM DOTS