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Streptococcus pneumoniae-induced inhibition of rat ependymal cilia is attenuated by antipneumolysin antibody

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journal contribution
posted on 29.11.2007, 17:56 by Robert A. Hirst, Bashir J. Mohammed, Timothy J. Mitchell, Peter W. Andrew, Christopher L. O'Callaghan
Ciliated ependymal cells line the ventricular surfaces and aqueducts of the brain. In ex vivo experiments, pneumolysin caused rapid inhibition of the ependymal ciliary beat frequency and caused ependymal cell disruption. Wild-type pneumococci and pneumococci deficient in pneumolysin caused ciliary slowing, but penicillin lysis of wild-type, not pneumolysin-deficient, pneumococci increased the extent of ciliary inhibition. This effect was abolished by antipneumolysin antibody. Ependymal ciliary stasis by purified pneumolysin was also blocked by the addition of antipneumolysin monoclonal antibodies. These data show that antibiotic lysis of Streptococcus pneumoniae can be detrimental to the ciliated ependyma and that antipneumolysin antibody may have a therapeutic potential.

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Citation

Infection and Immunity, 2004, 72(11), pp.6694-6698

Published in

Infection and Immunity

Publisher

American Society for Microbiology

Available date

29/11/2007

Notes

Copyright © 2004, American Society for Microbiology. All Rights Reserved. Also available from the publisher website at http://iai.asm.org/

Language

en

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