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Structural investigations of the RNA-binding properties of STAR proteins

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journal contribution
posted on 29.08.2014, 14:16 by Mikael Feracci, Jaelle Foot, Cyril Dominguez
STAR (signal transduction and activation of RNA) proteins are a family of RNA-binding proteins that regulate post-transcriptional gene regulation events at various levels, such as pre-mRNA alternative splicing, RNA export, translation and stability. Most of these proteins are regulated by signalling pathways through post-translational modifications, such as phosphorylation and arginine methylation. These proteins share a highly conserved RNA-binding domain, denoted STAR domain. Structural investigations of this STAR domain in complex with RNA have highlighted how a subset of STAR proteins specifically recognizes its RNA targets. The present review focuses on the structural basis of RNA recognition by this family of proteins.

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Citation

Biochemical Society Transactions, 2014, 42 (4), pp. 1141-1146

Author affiliation

/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Biological Sciences/Department of Biochemistry

Version

AM (Accepted Manuscript)

Published in

Biochemical Society Transactions

Publisher

Portland Press

issn

0300-5127

eissn

1470-8752

Copyright date

2014

Available date

01/02/2015

Publisher version

http://www.biochemsoctrans.org/content/42/4/1141

Notes

The final version of record is available at http://www.biochemsoctrans.org/content/42/4/1141

Language

en

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