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TIS11 family proteins and their roles in posttranscriptional gene regulation

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journal contribution
posted on 04.12.2013, 16:41 by Maria Baou, Andrew Jewell, John J. Murphy
Posttranscriptional regulation of gene expression of mRNAs containing adenine-uridine rich elements (AREs) in their 3' untranslated regions is mediated by a number of different proteins that interact with these elements to either stabilise or destabilise them. The present review concerns the TPA-inducible sequence 11 (TIS11) protein family, a small family of proteins, that appears to interact with ARE-containing mRNAs and promote their degradation. This family of proteins has been extensively studied in the past decade. Studies have focussed on determining their biochemical functions, identifying their target mRNAs, and determining their roles in cell functions and diseases.

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Citation

Journal of Biomedicine and Biotechnology, Volume 2009, Article ID 634520

Version

VoR (Version of Record)

Published in

Journal of Biomedicine and Biotechnology

Publisher

Hindawi Publishing Corporation

issn

1110-7243

eissn

1110-7251

Copyright date

2009

Available date

04/12/2013

Publisher version

http://www.hindawi.com/journals/bmri/2009/634520/

Language

en

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