TVviewing_mortality_ELSA_ATH-D-17-00498 R1 (002).pdf (297.93 kB)
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Television viewing and risk of mortality: Exploring the biological plausibility.

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journal contribution
posted on 23.03.2018, 15:11 by M Hamer, Thomas Yates, P Demakakos
Background and aims: Television (TV) viewing is a major component of leisure sedentary time, and has been consistently associated with cardiovascular disease. We examined the extent to which metabolic biomarkers explain the association between TV viewing and mortality. Methods: Participants (N = 8,451, aged 64.8 ± 9.9 yrs) were drawn from The English Longitudinal Study of Ageing (ELSA), a national prospective cohort study of community-dwelling men and women living in England. The individual participant data were linked with death records from the National Health Service registries from 2008 to 2012. Cox proportional hazards models were used to estimate the risk of death according to time spent watching TV, with biomarkers added in a stepwise fashion to estimate potential mediation. Results: Over an average follow up of 4 years (33,832 person years), there were 370 deaths. In models adjusted for comorbidities, psychosocial factors, and health behaviours including physical activity, there was an association between TV viewing and mortality (≥6 h per day vs. < 2 h per day [Ref]; hazard ratio = 1.98, 95% CI, 1.25, 3.15). Adjustment for inflammatory markers (C-reactive protein and fibrinogen) accounted for ∼15.7% of the association between TV viewing and mortality, but metabolic risk factors (HDL-cholesterol, triglycerides, glycated haemoglobin) did not contribute. Conclusions: The association between TV viewing and mortality was partly mediated by inflammatory markers, although the relationship remains largely unexplained.

History

Citation

Atherosclerosis, 2017, 263, pp. 151-155

Author affiliation

/Organisation/COLLEGE OF LIFE SCIENCES/School of Medicine/Diabetes Research Centre

Version

AM (Accepted Manuscript)

Published in

Atherosclerosis

Publisher

Elsevier

issn

0021-9150

eissn

1879-1484

Acceptance date

08/06/2017

Copyright date

2017

Available date

09/06/2018

Publisher version

https://www.sciencedirect.com/science/article/pii/S0021915017302733?via=ihub

Notes

The file associated with this record is under embargo until 12 months after publication, in accordance with the publisher's self-archiving policy. The full text may be available through the publisher links provided above.

Language

en

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