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The Leicester cerebral haemodynamics database: normative values and the influence of age and sex

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journal contribution
posted on 15.05.2017, 15:09 by Nikil Patel, Ronney B. Panerai, Victoria Haunton, Emmanuel Katsogridakis, Nazia P. Saeed, Angela Salinet, Fiona Brodie, Nazia Syed, Schnell D'Sa, Thompson G. Robinson
Normative values of physiological parameters hold significance in modern day clinical decision-making. Lack of such normative values has been a major hurdle in the translation of research into clinical practice. A large database containing uniform recordings was constructed to allow more robust estimates of normative ranges and also assess the influence of age and sex. Doppler recordings were performed on healthy volunteers in the same laboratory, using similar protocols and equipment. Beat-to-beat blood pressure, heart-rate, electrocardiogram, and end-tidal CO2 were measured continuously. Bilateral insonation of the middle cerebral arteries (MCAs) was performed using TCD following a 15 min stabilisation, and a 5 min baseline recording. Good quality Doppler recordings for both MCAs were obtained in 129 participants (57 female) with a median age of 57 years (range 20-82). Age was found to influence baseline haemodynamic and transfer function analysis parameters. Cerebral blood flow velocity and critical closing pressure were the only sex-related differences found, which was significantly higher in females than males. Normative values for cerebral haemodynamic parameters have been defined in a large, healthy population. Such age/sex-defined normal values can be used to reduce the burden of collecting additional control data in future studies, as well as to identify disease-associated changes.

History

Citation

Physiological Measurement, 2016, 37 (9), pp. 1485-1498

Author affiliation

/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicine/Department of Cardiovascular Sciences

Version

AM (Accepted Manuscript)

Published in

Physiological Measurement

Publisher

IOP Publishing

issn

0967-3334

eissn

1361-6579

Acceptance date

11/07/2016

Copyright date

2016

Available date

11/08/2017

Publisher version

http://iopscience.iop.org/article/10.1088/0967-3334/37/9/1485/meta;jsessionid=E9575AF29938413F79E0A431DD1A41A8.c2.iopscience.cld.iop.org

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The file associated with this record is embargoed until 12 months after the date of publication. The final published version may be available through the links above.

Language

en

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