The Nature of Shared Cortical Variability.pdf (3.72 MB)
Download file

The Nature of Shared Cortical Variability

Download (3.72 MB)
journal contribution
posted on 12.06.2017, 14:02 by I-Chun Lin, Michael Okun, Matteo Carandini, Kenneth D. Harris
Neuronal responses of sensory cortex are highly variable, and this variability is correlated across neurons. To assess how variability reflects factors shared across a neuronal population, we analyzed the activity of many simultaneously recorded neurons in visual cortex. We developed a simple model that comprises two sources of shared variability: a multiplicative gain, which uniformly scales each neuron's sensory drive, and an additive offset, which affects different neurons to different degrees. This model captured the variability of spike counts and reproduced the dependence of pairwise correlations on neuronal tuning and stimulus orientation. The relative contributions of the additive and multiplicative fluctuations could vary over time and had marked impact on population coding. These observations indicate that shared variability of neuronal populations in sensory cortex can be largely explained by two factors that modulate the whole population.

History

Citation

Neuron, 2015, 87 (3), pp. 644-656

Author affiliation

/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/MBSP Non-Medical Departments/Neuroscience, Psychology and Behaviour

Version

VoR (Version of Record)

Published in

Neuron

Publisher

Elsevier (Cell Press)

issn

0896-6273

eissn

1097-4199

Copyright date

2015

Available date

12/06/2017

Publisher version

http://www.sciencedirect.com/science/article/pii/S089662731500598X

Language

en