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The Speed of Increasing milk Feeds: a randomised controlled trial

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posted on 26.01.2017, 09:08 by Jane Abbott, Janet Berrington, Ursula Bowler, Elaine Boyle, Jon Dorling, Nicholas Embleton, Edmund Juszczak, Alison Leaf, Louise Linsell, Samantha Johnson, Kenny McCormick, William McGuire, Tracy Roberts, Ben Stenson
In the UK, 1-2% of infants are born very preterm (<32 weeks of gestation) or have very low birth weight (<1,500g). Very preterm infants are initially unable to be fed nutritional volumes of milk and therefore require intravenous nutrition. Milk feeding strategies influence several long and short term health outcomes including growth, survival, infection (associated with intravenous nutrition) and necrotising enterocolitis (NEC); with both infection and NEC being key predictive factors of long term disability. Currently there is no consistent strategy for feeding preterm infants across the UK. The SIFT trial will test two speeds of increasing milk feeds with the primary aim of determining effects on survival without moderate or severe neurodevelopmental disability at 24 months of age, corrected for prematurity. The trial will also examine many secondary outcomes including infection, NEC, time taken to reach full feeds and growth.

Funding

This research is funded by the National Institute for Health Research (NIHR) (NIHR HTA - 11/01/25).

History

Citation

BMC Pediatrics, 2017, 17(39)

Author affiliation

/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicine/Department of Health Sciences

Version

VoR (Version of Record)

Published in

BMC Pediatrics

Publisher

BioMed Central

issn

1471-2431

Acceptance date

16/01/2017

Copyright date

2017

Available date

04/05/2017

Publisher version

https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887-017-0794-z

Language

en

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