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The hypoxic tumour microenvironment

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journal contribution
posted on 10.10.2018, 15:25 by Varvara Petrova, Margherita Annicchiarico-Petruzzelli, Gerry Melino, Ivano Amelio
Cancer progression often benefits from the selective conditions present in the tumour microenvironment, such as the presence of cancer-associated fibroblasts (CAFs), deregulated ECM deposition, expanded vascularisation and repression of the immune response. Generation of a hypoxic environment and activation of its main effector, hypoxiainducible factor-1 (HIF-1), are common features of advanced cancers. In addition to the impact on tumour cell biology, the influence that hypoxia exerts on the surrounding cells represents a critical step in the tumorigenic process. Hypoxia indeed enables a number of events in the tumour microenvironment that lead to the expansion of aggressive clones from heterogeneous tumour cells and promote a lethal phenotype. In this article, we review the most relevant findings describing the influence of hypoxia and the contribution of HIF activation on the major components of the tumour microenvironment, and we summarise their role in cancer development and progression.

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Citation

Oncogenesis, 2018, 7:10

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VoR (Version of Record)

Published in

Oncogenesis

Publisher

Springer Nature

eissn

2157-9024

Acceptance date

04/10/2017

Copyright date

2018

Available date

10/10/2018

Publisher version

https://www.nature.com/articles/s41389-017-0011-9

Language

en

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