1-s2.0-S0960982214010367-main.pdf (2.62 MB)
Download file

The logic of circadian organization in Drosophila

Download (2.62 MB)
journal contribution
posted on 08.10.2015, 11:00 by S. Dissel, C. N. Hansen, Ö. Özkaya, M. Hemsley, Charalambos P. Kyriacou, E. Rosato
BACKGROUND: In the fruit fly Drosophila melanogaster, interlocked negative transcription/translation feedback loops provide the core of the circadian clock that generates rhythmic phenotypes. Although the current molecular model portrays the oscillator as cell autonomous, cross-talk among clock neurons is essential for robust cycling behavior. Nevertheless, the functional organization of the neuronal network remains obscure. RESULTS: Here we show that shortening or lengthening of the circadian period of locomotor activity can be obtained either by targeting different groups of clock cells with the same genetic manipulation or by challenging the same group of cells with activators and repressors of neuronal excitability. CONCLUSIONS: Based on these observations we interpret circadian rhythmicity as an emerging property of the circadian network and we propose an initial model for its architectural design.

History

Citation

Current Biology, 2014, 24 (19), pp. 2257-2266

Author affiliation

/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/MBSP Non-Medical Departments/Department of Genetics

Version

VoR (Version of Record)

Published in

Current Biology

Publisher

Elsevier (Cell Press)

eissn

1879-0445

Acceptance date

13/08/2014

Copyright date

2013

Available date

08/10/2015

Publisher version

http://www.sciencedirect.com/science/article/pii/S0960982214010367

Language

en