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The multifaceted effects of omega-3 polyunsaturated Fatty acids on the hallmarks of cancer

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journal contribution
posted on 04.08.2015, 09:12 by James Andrew Stephenson, Omer Al-Taan, Ali Arshad, Bruno Morgan, Matthew S. Metcalfe, Ashley Dennison
Omega-3 polyunsaturated fatty acids, in particular eicosapentaenoic acid, and docosahexaenoic acid have been shown to have multiple beneficial antitumour actions that affect the essential alterations that dictate malignant growth. In this review we explore the putative mechanisms of action of omega-3 polyunsaturated fatty acid in cancer protection in relation to self-sufficiency in growth signals, insensitivity to growth-inhibitory signals, apoptosis, limitless replicative potential, sustained angiogenesis, and tissue invasion, and how these will hopefully translate from bench to bedside.

History

Citation

Journal of Lipids, 2013, 2013, 261247

Author affiliation

/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicine/Department of Cancer Studies and Molecular Medicine

Version

VoR (Version of Record)

Published in

Journal of Lipids

Publisher

Hindawi Publishing Corporation

issn

2090-3030

eissn

2090-3049

Acceptance date

05/04/2013

Copyright date

2013

Available date

04/08/2015

Publisher version

http://www.hindawi.com/journals/jl/2013/261247/

Language

en

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