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The role of microRNAs (miRNA) in circadian rhythmicity

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journal contribution
posted on 24.10.2012, 09:12 by Mirko Pegoraro, Eran Tauber
MicroRNA (miRNA) is a recently discovered new class of small RNA molecules that have a significant role in regulating gene and protein expression. These small RNAs (∼22 nt) bind to 3′ untranslated regions (3′ UTRs) and induce degradation or repression of translation of their mRNA targets. Hundreds of miRNAs have been identified in various organisms and have been shown to play a significant role in development and normal cell functioning. Recently, a few studies have suggested that miRNAs may be an important regulators of circadian rhythmicity, providing a new dimension (posttranscriptional) of our understanding of biological clocks. Here, we describe the mechanisms of miRNA regulation, and recent studies attempting to identify clock miRNAs and their function in the circadian system.

History

Citation

Journal of Genetics, 2008, 87 (5), pp. 505-511

Version

VoR (Version of Record)

Published in

Journal of Genetics

Publisher

Indian Academy of Sciences

issn

0022-1333

eissn

0973-7731

Copyright date

2008

Available date

24/10/2012

Publisher version

http://link.springer.com/article/10.1007/s12041-008-0073-8

Language

English