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The scalability of common paradigms for assessment of cognitive function: A functional transcranial Doppler study.

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posted on 17.06.2022, 15:50 authored by Kannakorn Intharakham, Ronney B Panerai, Thompson G Robinson
Cognitive paradigms induce changes in cerebral blood flow (CBF) associated with increased metabolic demand, namely neurovascular coupling (NVC). We tested the hypothesis that the effect of complexity and duration of cognitive paradigms will either enhance or inhibit the NVC response. Bilateral CBF velocity (CBFV) in the middle cerebral arteries (MCAs) via transcranial Doppler ultrasound (TCD), blood pressure (BP), electrocardiogram (ECG) and end-tidal CO2 (EtCO2) of 16 healthy participants (aged 21-71 years) were simultaneously recorded at rest and during randomized paradigms of different complexities (naming words beginning with P-,R-,V- words and serial subtractions of 100-2,100-7,1000-17), and durations (5s, 30s and 60s). CBFV responses were population mean normalized from a 30-s baseline period prior to task initiation. A significant increase in bilateral CBFV response was observed at the start of all paradigms and provided a similar pattern in most responses, irrespective of complexity or duration. Although significant inter-hemispherical differences were found during performance of R-word and all serial subtraction paradigms, no lateralisation was observed in more complex naming word tasks. Also, the effect of duration was manifested at late stages of 100-7, but not for other paradigms. CBFV responses could not distinguish different levels of complexity or duration with a single presentation of the cognitive paradigm. Further studies of the ordinal scalability of the NVC response are needed with more advanced modelling techniques, or different types of neural stimulation.

Funding

Kannakorn Intharakham (KI) is supported by a PhD scholarship of the Ministry of Higher Education, Science, Research and Innovation of the Royal Thai Government, Grant number ST G5420. Professor Thompson G Robinson (TGR) is a National Institute for Health Research (NIHR) Senior Investigator, Grant number NIHR201309.

History

Citation

Intharakham K, Panerai RB, Robinson TG (2022) The scalability of common paradigms for assessment of cognitive function: A functional transcranial Doppler study. PLoS ONE 17(3): e0266048. https://doi.org/10.1371/journal. pone.0266048

Author affiliation

Department of Cardiovascular Sciences; NIHR Leicester Biomedical Research Centre

Version

VoR (Version of Record)

Published in

PLoS ONE

Volume

17

Issue

3

Pagination

e0266048

Publisher

Public Library of Science (PLoS)

issn

1932-6203

eissn

1932-6203

Acceptance date

14/10/2021

Copyright date

2022

Available date

17/06/2022

Language

eng