s12931-020-1279-4.pdf (494.44 kB)
Download file

The stability of blood Eosinophils in chronic obstructive pulmonary disease

Download (494.44 kB)
journal contribution
posted on 07.05.2020, 12:03 by GH Long, T Southworth, U Kolsum, GC Donaldson, JA Wedzicha, CE Brightling, D Singh
Blood eosinophils are a predictive biomarker of inhaled corticosteroid response in chronic obstructive pulmonary disease (COPD). We investigated blood eosinophil stability over 1 year using the Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2019 thresholds of < 100, 100- < 300 and ≥ 300 eosinophils/μL in 225 patients from the COPDMAP cohort. Blood eosinophils showed good stability (rho: 0.71, p < 0.001, ICC 0.84), and 69.3% of patients remained in the same eosinophil category at 1 year. 85.3% of patients with eosinophils < 100 cells/μL had stable counts. The majority of blood eosinophil counts remain stable over 1 year using the GOLD 2019 thresholds.

Funding

This study was funded by the MRC (United Kingdom). DS is supported by the NIHR Manchester BRC.

History

Citation

Respiratory Research, 2020, Vol. 21:15

Author affiliation

Institute for Lung Health

Version

VoR (Version of Record)

Published in

Respiratory Research

Volume

21

Issue

1

Publisher

BMC

issn

1465-9921

eissn

1465-993X

Acceptance date

05/01/2020

Copyright date

2020

Publisher version

https://respiratory-research.biomedcentral.com/articles/10.1186/s12931-020-1279-4#Abs1

Language

eng

Usage metrics

Categories

Licence

Exports