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The value of transcriptomics in advancing knowledge of the immune response and diagnosis in tuberculosis

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journal contribution
posted on 09.05.2019, 15:13 by Akul Singhania, Robert J. Wilkinson, Marc Rodrigue, Pranabashis Haldar, Anne O’Garra
Blood transcriptomics analysis of tuberculosis has revealed an interferon-inducible gene signature that diminishes in expression after successful treatment; this promises improved diagnostics and treatment monitoring, which are essential for the eradication of tuberculosis. Sensitive radiography revealing lung abnormalities and blood transcriptomics have demonstrated heterogeneity in patients with active tuberculosis and exposed asymptomatic people with latent tuberculosis, suggestive of a continuum of infection and immune states. Here we describe the immune response to infection with Mycobacterium tuberculosis revealed through the use of transcriptomics, as well as differences among clinical phenotypes of infection that might provide information on temporal changes in host immunity associated with evolving infection. We also review the diverse blood transcriptional signatures, composed of small sets of genes, that have been proposed for the diagnosis of tuberculosis and the identification of at-risk asymptomatic people and suggest novel approaches for the development of such biomarkers for clinical use.

Funding

A.S., R.J.W. and A.O.G. were funded by The Francis Crick Institute (Crick 10126 and Crick 10468 for A.O.G. and A.S., and Crick 10128 for R.J.W.), which receives its core funding from Cancer Research UK, the UK Medical Research Council and the Wellcome Trust. R.J.W. was supported by the Wellcome Trust (104803 and 203135); MRC South Africa under strategic health innovation partnerships EDCTP SR1A 2015-1065 and the US National Institutes of Health (019 AI 111276 and UO1AI115940). P.H. was supported by NIHR Leicester Biomedical Research Centre and the University of Leicester. M.R. was supported by Medical Diagnostic Discovery Department, bioMérieux SA, Marcy l’Etoile, France.

History

Citation

Nature Immunology, 2018, 19, pp. 1159–1168

Author affiliation

/Organisation/COLLEGE OF LIFE SCIENCES/School of Medicine/Department of Infection, Immunity and Inflammation

Version

AM (Accepted Manuscript)

Published in

Nature Immunology

Publisher

Nature Research (part of Springer Nature)

issn

1529-2908

Acceptance date

28/08/2018

Copyright date

2018

Available date

09/05/2019

Publisher version

https://www.nature.com/articles/s41590-018-0225-9

Notes

Supplementary information is available for this paper at https://doi.org/10.1038/s41590-018-0225-9.

Language

en

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