Toward male individualization with rapidly mutating y-chromosomal short tandem repeats..pdf (991.95 kB)
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Toward male individualization with rapidly mutating y-chromosomal short tandem repeats.

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posted on 24.02.2016, 10:53 by K. N. Ballantyne, A. Ralf, R. Aboukhalid, N. M. Achakzai, M. J. Anjos, Q. Ayub, J. Balažic, J. Ballantyne, D. J. Ballard, B. Berger, C. Bobillo, M. Bouabdellah, H. Burri, T. Capal, S. Caratti, J. Cárdenas, F. Cartault, E. F. Carvalho, M. Carvalho, B. Cheng, M. D. Coble, D. Comas, D. Corach, M. E. D'Amato, S. Davison, P. de Knijff, M. C. De Ungria, R. Decorte, T. Dobosz, B. M. Dupuy, S. Elmrghni, M. Gliwiński, S. C. Gomes, L. Grol, C. Haas, E. Hanson, J. Henke, L. Henke, F. Herrera-Rodríguez, C. R. Hill, G. Holmlund, K. Honda, U. D. Immel, S. Inokuchi, Mark A. Jobling, M. Kaddura, J. S. Kim, S. H. Kim, W. Kim, Turi Emma King, E. Klausriegler, D. Kling, L. Kovačević, L. Kovatsi, P. Krajewski, S. Kravchenko, M. H. Larmuseau, E. Y. Lee, R. Lessig, L. A. Livshits, D. Marjanović, M. Minarik, N. Mizuno, H. Moreira, N. Morling, M. Mukherjee, P. Munier, J. Nagaraju, F. Neuhuber, S. Nie, P. Nilasitsataporn, T. Nishi, H. H. Oh, J. Olofsson, V. Onofri, J. U. Palo, H. Pamjav, W. Parson, M. Petlach, C. Phillips, R. Ploski, S. P. Prasad, D. Primorac, G. A. Purnomo, J. Purps, H. Rangel-Villalobos, K. Rębała, B. Rerkamnuaychoke, D. R. Gonzalez, C. Robino, L. Roewer, A. Rosa, A. Sajantila, A. Sala, J. M. Salvador, P. Sanz, C. Schmitt, A. K. Sharma, D. A. Silva, K. J. Shin, T. Sijen, M. Sirker, D. Siváková, V. Skaro, C. Solano-Matamoros, L. Souto, V. Stenzl, H. Sudoyo, D. Syndercombe-Court, A. Tagliabracci, D. Taylor, A. Tillmar, I. S. Tsybovsky, C. Tyler-Smith, K. J. van der Gaag, D. Vanek, A. Völgyi, D. Ward, P. Willemse, E. P. Yap, R. Y. Yong, I. Z. Pajnič, M. Kayser
Relevant for various areas of human genetics, Y-chromosomal short tandem repeats (Y-STRs) are commonly used for testing close paternal relationships among individuals and populations, and for male lineage identification. However, even the widely used 17-loci Yfiler set cannot resolve individuals and populations completely. Here, 52 centers generated quality-controlled data of 13 rapidly mutating (RM) Y-STRs in 14,644 related and unrelated males from 111 worldwide populations. Strikingly, >99% of the 12,272 unrelated males were completely individualized. Haplotype diversity was extremely high (global: 0.9999985, regional: 0.99836-0.9999988). Haplotype sharing between populations was almost absent except for six (0.05%) of the 12,156 haplotypes. Haplotype sharing within populations was generally rare (0.8% nonunique haplotypes), significantly lower in urban (0.9%) than rural (2.1%) and highest in endogamous groups (14.3%). Analysis of molecular variance revealed 99.98% of variation within populations, 0.018% among populations within groups, and 0.002% among groups. Of the 2,372 newly and 156 previously typed male relative pairs, 29% were differentiated including 27% of the 2,378 father-son pairs. Relative to Yfiler, haplotype diversity was increased in 86% of the populations tested and overall male relative differentiation was raised by 23.5%. Our study demonstrates the value of RM Y-STRs in identifying and separating unrelated and related males and provides a reference database.

History

Citation

Human Mutation, 2014, 35 (8), pp. 1021-1032

Author affiliation

/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/MBSP Non-Medical Departments/Department of Genetics

Version

VoR (Version of Record)

Published in

Human Mutation

Publisher

Wiley for Human Genome Variation Society

issn

1059-7794

eissn

1098-1004

Acceptance date

26/05/2014

Copyright date

2014

Available date

24/02/2016

Publisher version

http://onlinelibrary.wiley.com/doi/10.1002/humu.22599/abstract

Language

en