Traffic pollution and the incidence of cardiorespiratory outcomes in an adult cohort in London.pdf (363.63 kB)
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Traffic pollution and the incidence of cardiorespiratory outcomes in an adult cohort in London.

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journal contribution
posted on 28.06.2019, 15:04 by IM Carey, HR Anderson, RW Atkinson, S Beevers, DG Cook, D Dajnak, J Gulliver, FJ Kelly
OBJECTIVES: The epidemiological evidence for adverse health effects of long-term exposure to air and noise pollution from traffic is not coherent. Further, the relative roles of background versus near traffic pollution concentrations in this process are unclear. We investigated relationships between modelled concentrations of air and noise pollution from traffic and incident cardiorespiratory disease in London. METHODS: Among 211 016 adults aged 40-79 years registered in 75 Greater London practices between 2005 and 2011, the first diagnosis for a range of cardiovascular and respiratory outcomes were identified from primary care and hospital records. Annual baseline concentrations for nitrogen oxide (NOx), particulate matter with a median aerodynamic diameter <2.5 μm (PM2.5) attributable to exhaust and non-exhaust sources, traffic intensity and noise were estimated at 20 m2 resolution from dispersion models, linked to clinical data via residential postcode. HRs were adjusted for confounders including smoking and area deprivation. RESULTS: The largest observed associations were between traffic-related air pollution and heart failure (HR=1.10 for 20 μg/m3 change in NOx, 95% CI 1.01 to 1.21). However, no other outcomes were consistently associated with any of the pollution indicators, including noise. The greater variations in modelled air pollution from traffic between practices, versus within, hampered meaningful fine spatial scale analyses. CONCLUSIONS: The associations observed with heart failure may suggest exacerbatory effects rather than underlying chronic disease. However, the overall failure to observe wider associations with traffic pollution may reflect that exposure estimates based on residence inadequately represent the relevant pattern of personal exposure, and future studies must address this issue.

Funding

This work was funded under the cross research council Environmental Exposure and Health Initiative with funds from the Natural Environment Research Council, the Medical Research Council, and the Department of Health [Grant number NE/I0078571]. Clinical Practice Research Datalink is owned by the Secretary of State of the UK Department of Health and operates within the MHRA. Clinical Practice Research Datalink has received funding from the MHRA, Wellcome Trust, Medical Research Council, NIHR Health Technology Assessment programme, Innovative Medicine Initiative, UK Department of Health, Technology Strategy Board, Seventh Framework Programme EU, various universities, contract research organisations, and pharmaceutical companies.

History

Citation

Occupational and Environmental Medicine, 2016, 73 (12), pp. 849-856

Author affiliation

/Organisation/COLLEGE OF SCIENCE AND ENGINEERING/School of Geography, Geology and the Environment

Version

VoR (Version of Record)

Published in

Occupational and Environmental Medicine

Publisher

BMJ Publishing Group for Royal College of Physicians of London, Faculty of Occupational Medicine

eissn

1470-7926

Acceptance date

25/05/2016

Copyright date

2016

Available date

28/06/2019

Publisher version

https://oem.bmj.com/content/73/12/849

Language

en