File(s) under permanent embargo

Reason: This item is currently closed access.

Treating the exercise problem in COPD

journal contribution
posted on 04.09.2015, 13:58 by Michael C. Steiner, Neil J. Greening
The inability to be physically active is one of the key complaints expressed by patients with COPD. This is best considered as an exercise problem because it is the quantitative restriction to physical capacity more than the sensation of breathlessness or fatigue during exercise (something we all experience) that is the abnormal symptom. There is now a convincing body of evidence indicating that skeletal muscle dysfunction is a frequent and clinically relevant feature of COPD that contributes significantly to reduced exercise performance and, indeed, mortality independently from the severity of lung function impairment.1 The cause of this dysfunction has been debated, but a long-term downward spiral of inactivity and deconditioning is the key feature of its natural history, although other disease-related factors (eg, hypoxia, drug therapy, systemic inflammation) may contribute in selected patients.[opening paragraph]

History

Citation

Chest, 2014, 146 (4), pp. 878-880

Author affiliation

/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicine/Department of Infection, Immunity and Inflammation

Version

VoR (Version of Record)

Published in

Chest

Publisher

American College of Chest Physicians (ACCP)

issn

0012-3692

eissn

1931-3543

Copyright date

2014

Publisher version

http://journal.publications.chestnet.org/article.aspx?articleid=1912461

Notes

The file associated with this record is embargoed while permission to archive is sought from the publisher. The final published version may be available through the links above.

Language

en