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Ultrasound measurement of brain tissue movement in humans: A systematic review

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journal contribution
posted on 12.03.2020, 14:32 by Jonathan Ince, Meshal Alharbi, Jatinder S Minhas, Emma ML Chung
It has long been suggested that ultrasound could be used to measure brain tissue pulsations in humans, but potential clinical applications are relatively unexplored. The aim of this systematic review was to explore and synthesise available literature on ultrasound measurement of brain tissue motion in humans. Our systematic review was designed to include predefined study selection criteria, quality evaluation, and a data extraction pro-forma, registered prospectively on PROSPERO (CRD42018114117). The systematic review was conducted by two independent reviewers. Ten studies were eligible for the evidence synthesis and qualitative evaluation. All eligible studies confirmed that brain tissue motion over the cardiac cycle could be measured using ultrasound; however, data acquisition, analysis, and outcomes varied. The majority of studies used tissue pulsatility imaging, with the right temporal window as the acquisition point. Currently available literature is largely exploratory, with measurements of brain tissue displacement over a narrow range of health conditions and ages. Explored health conditions include orthostatic hypotension and depression. Further studies are needed to assess variability in brain tissue motion estimates across larger cohorts of healthy subjects and in patients with various medical conditions. This would be important for informing sample size estimates to ensure future studies are appropriately powered. Future research would also benefit from a consistent framework for data analysis and reporting, to facilitate comparative research and meta-analysis. Following standardisation and further healthy participant studies, future work should focus on assessing the clinical utility of brain tissue pulsation measurements in cerebrovascular disease states.

History

Citation

Ultrasound, Dec. 2019

Author affiliation

College of Life Sciences

Version

AM (Accepted Manuscript)

Published in

Ultrasound

Publisher

SAGE Publications for British Medical Ultrasound Society

issn

1742-271X

eissn

1743-1344

Acceptance date

01/12/2019

Copyright date

2019

Publisher version

https://journals.sagepub.com/doi/abs/10.1177/1742271X19894601?journalCode=ultb#articleCitationDownloadContainer

Language

English