s13063-018-3126-1.pdf (775.75 kB)
Download file

Update on the General Practice Optimising Structured Monitoring to Improve Clinical Outcomes in Type 2 Diabetes (GP-OSMOTIC) trial: statistical analysis plan for a multi-centre randomised controlled trial.

Download (775.75 kB)
journal contribution
posted on 16.09.2019, 13:48 by S Thuraisingam, P Chondros, M Catchpool, K Dalziel, J-A Manski-Nankervis, J Speight, E Holmes-Truscott, R Audehm, J Chiang, I Blackberry, D O'Neal, K Khunti, J Best, J Furler
BACKGROUND: General Practice Optimising Structured Monitoring to Improve Clinical Outcomes in Type 2 Diabetes (GP-OSMOTIC) is a multicentre, individually randomised controlled trial aiming to compare the use of intermittent retrospective continuous glucose monitoring (r-CGM) to usual care in patients with type 2 diabetes attending general practice. The study protocol was published in the British Medical Journal Open and described the principal features of the statistical methods that will be used to analyse the trial data. This paper provides greater detail on the statistical analysis plan, including background and justification for the statistical methods chosen, in accordance with SPIRIT guidelines. OBJECTIVE: To describe in detail the data management process and statistical methods that will be used to analyse the trial data. METHODS: An overview of the trial design and primary and secondary research questions are provided. Sample size assumptions and calculations are explained, and randomisation and data management processes are described in detail. The planned statistical analyses for primary and secondary outcomes and sub-group analyses are specified along with the intended table layouts for presentation of the results. CONCLUSION: In accordance with best practice, all analyses outlined in the document are based on the aims of the study and have been pre-specified prior to the completion of data collection and outcome analyses. TRIAL REGISTRATION: Australian New Zealand Clinical Trials Registry, ACTRN12616001372471 . Registered on 3 August 2016.

Funding

Funding for this study has been provided by the National Health and Medical Research Council Project Grant (ID APP1104241). Additional funding has been provided by Sanofi Australia. Libre Pro reader devices, sensors, and software will be provided by Abbott Diabetes Care as in-kind support. Study sponsor and funders have had no role in the development of this analysis plan.

History

Citation

Trials, 2019, volume 20, Article number: 93

Author affiliation

/Organisation/COLLEGE OF LIFE SCIENCES/School of Medicine/Diabetes Research Centre

Version

VoR (Version of Record)

Published in

Trials

Publisher

BMC (part of Springer Nature)

eissn

1745-6215

Acceptance date

11/12/2018

Copyright date

2019

Available date

16/09/2019

Publisher version

https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-018-3126-1

Language

en