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Visual Dysfunction in Huntington's Disease: A Systematic Review.

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journal contribution
posted on 22.05.2019, 11:30 by Amita Dhalla, Susila Pallikadavath, Claire V. Hutchinson
It is well-documented that patients with Huntington's disease (HD) exhibit specific deficits in visual cognition. A less well-documented literature also exists that suggests people with HD experience a number of disease-related changes to more rudimentary sensory visual processing. Here, we review evidence for the effects of HD on the integrity of the early visual pathways in humans along with changes to low-level visual sensitivity. We find evidence for reduced structural and functional integrity of the visual pathways, marked by retinal thinning, reduced VEP amplitude, and cell loss and thinning in visual cortex. We also find evidence of visual perceptual deficits, particularly for colour and motion. We suggest that future studies with well-defined HD and HD-related groups in appropriate numbers that systematically examine the relationship between structural changes to the visual system, basic visual perceptual deficits and disease stage/severity are therefore likely to yield promising results.

History

Citation

Journal of Huntington's Disease, 2019, 8 (2), pp. 233-242

Author affiliation

/Organisation/COLLEGE OF LIFE SCIENCES/Biological Sciences/Neuroscience, Psychology and Behaviour

Version

AM (Accepted Manuscript)

Published in

Journal of Huntington's Disease

Publisher

IOS Press

eissn

1879-6400

Copyright date

2019

Available date

22/05/2019

Publisher version

https://content.iospress.com/articles/journal-of-huntingtons-disease/jhd180340

Language

en