Visualisation of exhaled breath metabolites reveals distinct diagnostic signatures for acute cardiorespiratory breathlessness
journal contributionposted on 2023-01-20, 11:33 authored by Wadah Ibrahim, Michael J Wilde, Rebecca Cordell, Matthew Richardson, Dahlia Salman, Robert Free, Bo Zhao, Amisha Singapuri, Beverley Hargadon, Erol Gaillard, Toru Suzuki, Leong Ng, Tim Coats, Paul Thomas, Paul S Monks, Chris Brightling, Neil Greening, Salman Siddiqui
Breath analysis can be a useful noninvasive way to detect disease. Here, Ibrahim et al. studied the volatile organic compound (VOC) signatures associated with acute cardiorespiratory diseases in patients presenting breathlessness. Using two-dimensional gas chromatography and mass spectrometry, the authors found clusters of VOCs associated with acute heart failure, asthma, chronic obstructive pulmonary disease, and pneumonia. These breath biomarkers correlated with blood-based biomarkers. An acute disease VOC score based on a 101-biomarker panel was associated with 2-year all-cause mortality. This study demonstrates how breathomics can help diagnose disease and further our understanding of metabolic subgroups.
East Midlands Breathomics Pathology Node (EMBER)
Medical Research CouncilFind out more...
Institutional Strategic Support Fund
Wellcome TrustFind out more...
Attenuating the effects of hospital-associated disability in exacerbations of Chronic Obstructive Pulmonary Disease using an anabolic intervention: a randomised controlled feasibility study
NIHR AcademyFind out more...