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Visualisation of exhaled breath metabolites reveals distinct diagnostic signatures for acute cardiorespiratory breathlessness

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journal contribution
posted on 2023-01-20, 11:33 authored by Wadah Ibrahim, Michael J Wilde, Rebecca Cordell, Matthew Richardson, Dahlia Salman, Robert Free, Bo Zhao, Amisha Singapuri, Beverley Hargadon, Erol Gaillard, Toru Suzuki, Leong Ng, Tim Coats, Paul Thomas, Paul S Monks, Chris Brightling, Neil Greening, Salman Siddiqui
Breath analysis can be a useful noninvasive way to detect disease. Here, Ibrahim et al. studied the volatile organic compound (VOC) signatures associated with acute cardiorespiratory diseases in patients presenting breathlessness. Using two-dimensional gas chromatography and mass spectrometry, the authors found clusters of VOCs associated with acute heart failure, asthma, chronic obstructive pulmonary disease, and pneumonia. These breath biomarkers correlated with blood-based biomarkers. An acute disease VOC score based on a 101-biomarker panel was associated with 2-year all-cause mortality. This study demonstrates how breathomics can help diagnose disease and further our understanding of metabolic subgroups.

Funding

East Midlands Breathomics Pathology Node (EMBER)

Medical Research Council

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Institutional Strategic Support Fund

Wellcome Trust

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Attenuating the effects of hospital-associated disability in exacerbations of Chronic Obstructive Pulmonary Disease using an anabolic intervention: a randomised controlled feasibility study

NIHR Academy

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Research funding was provided by the MRC and EPSRC Stratified Medicine Grant for Molecular Pathology Nodes (Grant No. MR/N005880/1). The research was supported by the National Institute for Health Research (NIHR )Leicester Biomedical Research Centre and NIHR, Leicester Clinical Research Facility, the Leicester Wellcome Trust ISSF (Award No. 204801/Z/16/Z), and the Midlands Asthma and Allergy Research Association(MAARA) to whom we are extremely grateful. N.J.G. is funded by a NIHR post doctoral fellowship (PDF 2017 10 052)

History

Author affiliation

Department of Respiratory Sciences, University of Leicester

Version

AM (Accepted Manuscript)

Published in

Science Translational Medicine

Volume

14

Issue

671

Pagination

eabl5849

Publisher

American Association for the Advancement of Science

issn

1946-6234

eissn

1946-6242

Copyright date

2022

Available date

2023-01-20

Publisher DOI

Spatial coverage

United States

Language

eng

Publisher version

Usage metrics

University of Leicester PublicationsUniversity of Leicester Publications

Categories

Keywords

EMBER ConsortiumHumansAsthmaDyspneaAcute DiseaseBreath TestsHeart FailureVolatile Organic CompoundsBiomarkers

Licence

CC BY 4.0

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