When Two Drugs Are not Better than One - J Affect Dis (1).pdf (137.71 kB)
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When two drugs are not better than one: Treating mood symptoms in patients with chronic opioid use.

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posted on 04.09.2019, 10:57 by Golo Kronenberg, Deepti Desai, Ion Anghelescu
[First paragraph] Drug overdose fatalities in the United States have reached an all-time high. Deplorably, many other countries are following suit. The Centers for Disease Control and Prevention reports that, in 2017, opioids were involved in 47,600 overdose deaths (CDC, 2018), a number which dwarfs the number of car crash fatalities in the same year. Regrettably, the ‘Inexorable March to Death and Addiction’ (Theisen and Davies, 2019) is fueled, to a large part, by an invidious trend of medical overprescribing and misprescribing, which disproportionately affects patients with mental health disorders (Seal et al., 2012). Moreover, accruing evidence suggests that opioid use may directly precipitate depressive symptoms. For example, a large retrospective cohort study collating data from three independent healthcare systems including the Veterans Health Administration demonstrated that duration of opioid use is associated with the new onset of depression (Scherrer et al., 2016a). The risk of developing treatment-resistant depression was also found to grow with duration of opioid exposure (Scherrer et al., 2016b).

History

Citation

Journal of Affective Disorders, 2019, 259, pp. 173-174

Author affiliation

/Organisation/COLLEGE OF LIFE SCIENCES/School of Medicine/Department of Cardiovascular Sciences

Version

AM (Accepted Manuscript)

Published in

Journal of Affective Disorders

Publisher

Elsevier for International Society for Affective Disorders

eissn

1573-2517

Acceptance date

17/08/2019

Copyright date

2019

Publisher version

https://www.sciencedirect.com/science/article/pii/S0165032719317860?via=ihub

Notes

The file associated with this record is under embargo until 12 months after publication, in accordance with the publisher's self-archiving policy. The full text may be available through the publisher links provided above.

Language

en

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