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Withdrawal of antihypertensive medication: a systematic review.

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journal contribution
posted on 22.06.2017, 13:03 by Veronika van der Wardt, Jennifer K. Harrison, Tomas Welsh, Simon Conroy, John Gladman
Although antihypertensive medication is usually continued indefinitely, observations during wash-out phases in hypertension trials have shown that withdrawal of antihypertensive medication might be well tolerated to do in a considerable proportion of people. A systematic review was completed to determine the proportion of people remaining normotensive for 6 months or longer after cessation of antihypertensive therapy and to investigate the safety of withdrawal. The mean proportion adjusted for sample size of people remaining below each study’s threshold for hypertension treatment was 0.38 at 6 months [95% confidence interval (CI) 0.37–0.49; 912 participants], 0.40 at 1 year (95% CI 0.40–0.40; 2640 participants) and 0.26 at 2 years or longer (95% CI 0.26–0.27; 1262 participants). Monotherapy, lower blood pressure before withdrawal and body weight were reported as predictors for successful withdrawal. Adverse events were more common in those who withdrew but were minor and included headache, joint pain, palpitations, oedema and a general feeling of being unwell. Prescribers should consider offering patients with well controlled hypertension a trial of withdrawal of antihypertensive treatment with subsequent regular blood pressure monitoring.

History

Citation

Journal of Hypertension, 2017, 35:000–000

Author affiliation

/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicine/Department of Health Sciences

Version

VoR (Version of Record)

Published in

Journal of Hypertension

Publisher

Wolters Kluwer Health, Inc.

issn

0263-6352

eissn

1473-5598

Acceptance date

17/04/2017

Copyright date

2017

Available date

22/06/2017

Publisher version

https://insights.ovid.com/crossref?an=00004872-900000000-97726

Language

en

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