[Ca2+]i oscillations in ASM: relationship with persistent airflow obstruction in asthma..pdf (295.5 kB)
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[Ca2+]i oscillations in ASM: relationship with persistent airflow obstruction in asthma.

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journal contribution
posted on 13.01.2016, 11:00 by David Sweeney, Fay Hollins, Edith Gomez, Ruth Mary Saunders, R.A. John Challiss, Christopher E. Brightling
The cause of airway smooth muscle (ASM) hypercontractility in asthma is not fully understood. The relationship of spontaneous intracellular calcium oscillation frequency in ASM to asthma severity was investigated. Oscillations were increased in subjects with impaired lung function abolished by extracellular calcium removal, attenuated by caffeine and unaffected by verapamil or nitrendipine. Whether modulation of increased spontaneous intracellular calcium oscillations in ASM from patients with impaired lung function represents a therapeutic target warrants further investigation.

History

Citation

Respirology, 2014, 19 (5), pp. 763-766

Author affiliation

/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicine/Department of Infection, Immunity and Inflammation

Version

VoR (Version of Record)

Published in

Respirology

Publisher

Wiley for Asian Pacific Society of Respirology

issn

1323-7799

eissn

1440-1843

Copyright date

2014

Available date

13/01/2016

Publisher version

http://onlinelibrary.wiley.com/doi/10.1111/resp.12318/abstract

Language

en