[Ca2+]i oscillations in ASM: relationship with persistent airflow obstruction in asthma.
journal contributionposted on 13.01.2016, 11:00 by David Sweeney, Fay Hollins, Edith Gomez, Ruth Mary Saunders, R.A. John Challiss, Christopher E. Brightling
The cause of airway smooth muscle (ASM) hypercontractility in asthma is not fully understood. The relationship of spontaneous intracellular calcium oscillation frequency in ASM to asthma severity was investigated. Oscillations were increased in subjects with impaired lung function abolished by extracellular calcium removal, attenuated by caffeine and unaffected by verapamil or nitrendipine. Whether modulation of increased spontaneous intracellular calcium oscillations in ASM from patients with impaired lung function represents a therapeutic target warrants further investigation.
CitationRespirology, 2014, 19 (5), pp. 763-766
Author affiliation/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicine/Department of Infection, Immunity and Inflammation
VersionVoR (Version of Record)
PublisherWiley for Asian Pacific Society of Respirology
airway hyperresponsivenessairway smooth muscleasthmacalciumoscillationsAdultAgedAsthmaBiopsyCaffeineCalcium SignalingCase-Control StudiesFemaleForced Expiratory VolumeHumansMaleMiddle AgedMuscle, SmoothNitrendipinePulmonary Disease, Chronic ObstructiveRespiratory MusclesSeverity of Illness IndexVerapamilVital Capacity