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miR-24 affects hair follicle morphogenesis targeting Tcf-3

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journal contribution
posted on 06.01.2016, 10:42 by I. Amelio, A. M. Lena, E. Bonanno, G. Melino, E. Candi
During embryonic development, hair follicles (HFs) develop from an epidermal–mesenchymal cross talk between the ectoderm progenitor layer and the underlying dermis. Epidermal stem cell activation represents a crucial point both for HF morphogenesis and for hair regeneration. miR-24 is an anti-proliferative microRNA (miRNA), which is induced during differentiation of several cellular systems including the epidermis. Here, we show that miR-24 is expressed in the HF and has a role in hair morphogenesis. We generated transgenic mice ectopically expressing miR-24 under the K5 promoter. The K5::miR-24 animals display a marked defect in HF morphogenesis, with thinning of hair coat and altered HF structure. Expression of miR-24 alters the normal process of hair keratinocyte differentiation, leading to altered expression of differentiation markers. MiR-24 directly represses the hair keratinocyte stemness regulator Tcf-3. These results support the notion that microRNAs, and among them miR-24, have an important role in postnatal epidermal homeostasis.

History

Citation

Cell Death and Disease (2013) 4, e922

Version

VoR (Version of Record)

Published in

Cell Death and Disease (2013) 4

Publisher

Nature Publishing Group for Associazione Differenziamento e Morte Cellulare

issn

2041-4889

eissn

2041-4889

Acceptance date

30/09/2013

Available date

06/01/2016

Publisher version

http://www.nature.com/cddis/journal/v4/n11/full/cddis2013426a.html

Language

en

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