2018AlzaraaAMD december 18.pdf (4.7 MB)
Download file

Microbubble distribution and incorporation in an ex-vivo perfused porcine

Download (4.7 MB)
thesis
posted on 20.12.2018, 11:50 by Ahmed Alzaraa
This thesis describes the behaviour and distribution of microbubbles using ultrasound and the relevant histological changes that occur upon the application of microwave energy in an exvivo perfused porcine liver model. The research was conducted in the laboratories of the Department of Molecular Medicine and Transplant Biology at Leicester General Hospital. The department has a long-standing interest in bio-artificial liver and basic investigation of tissue ablation techniques. To do this, the department runs an ex-vivo porcine liver model and has considerable experience in this field. This model is perfused with autologous blood. It accurately simulates the in-vivo situation, but removes some of the extraneous and confounding components associated with normal physiological and metabolic responses. This allows for extremely careful and reproducible adjustments of inflow and outflow parameters and is ideal for basic investigation of blood flow, and anything affected by this including substances infused into the liver.

History

Supervisor(s)

Lloyd, David; West, Kevin; Morgan, Bruno

Date of award

10/12/2018

Author affiliation

Department of Cancer Studies & Molecular Medicine

Awarding institution

University of Leicester

Qualification level

Doctoral

Qualification name

MD

Language

en

Usage metrics

Categories

Keywords

Exports